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NEMO Flyers for Exploitable Results


  • Ask, M., Mapelli, V., Höck, H., Olsson, L. Bettiga, M. 2013. Engineering glutathione biosynthesis of Saccharomyces cerevisiae for increased robustness to inhibitors in pretreated lignocellulosic materials. Microbial Cell Factories 2013, 12:87, doi: 10.1186/1475-2859-12-87, 2013 Oct 1.

  • Ask M, Bettiga M, Duraiswamy VR and Olsson L. Pulsed addition of HMF and furfural to batch-grown xylose-utilizing Saccharomyces cerevisiae results in different physiological responses in glucose and xylose consumption phase Biotechnology for Biofuels 2013, 6:181  doi:10.1186/1754-6834-6-181, 2013 Dec 16.

  • Demeke MM, Dietz H, Li Y, Foulquié-Moreno MR, Mutturi S, Deprez S, Den Abt T, Bonini BM, Liden G, Dumortier F, Verplaetse A, Boles E, Thevelein JM. 2013. Development of a D-xylose fermenting and inhibitor tolerant industrial Saccharomyces cerevisiae strain with high performance in lignocellulose hydrolysates using metabolic and evolutionary engineering. Biotechnol Biofuels. 6(1):89, doi: 10.1186/1754-6834-6-89, 2013 Jun 21.

  • Farwick A, Bruder S, Schadeweg V, Oreb M, Boles E. 2014. Engineering of yeast hexose transporters to transport D-xylose without inhibition by D-glucose. Proc Natl Acad Sci U S A., 111(14) 5159-64, 2014 Apr 8. doi: 10.1073/pnas.1323464111. Epub 2014 Mar 24.

  • Hubmann G, Mathé1 L, Foulquié-Moreno, MR, Duitama J, Nevoigt E, and Thevelein JM. 2013.  Identification of multiple interacting alleles conferring low glycerol and high ethanol yield in Saccharomyces cerevisiae ethanolic fermentation. Biotechnology for Biofuels 2013, 6:87  doi:10.1186/1754-6834-6-87, 2013 Jun 11.

  • Martani, F., Fossati, T., Posteri, R., Porro, D. and Branduardi, P. 2013. Different response to acetic acid stress in Saccharomyces cerevisiae wild type and L-ascorbic acid producing strains, Yeast. 30(9):365-78. doi: 10.1002/yea.2969, Epub 2013 Jul 30.

  • Mutturi S and Liden G. 2013. Effect of temperature on simultaneous saccharification and fermentation of pretreated spruce and arundo. Ind. Eng. Chem. Res.  52, 1244−1251.

  • Mutturi S and Lidén G. 2014. Model- based estimation of optimal temperature profile during simultaneous saccharification and fermentation of Arundo donax. Biotechnol. Bioeng. 111, 866-875.

  • Pais TM, Foulquié-Moreno MR, Hubmann G, Duitama J, Swinnen S, Goovaerts A, Dumortier F, and Thevelein JM. 2013. Comparative polygenic analysis of maximal ethanol accumulation capacity and tolerance to high ethanol levels of cell proliferation in yeast. PLOS, Genetics, doi: 10.1371/journal.pgen.1003548, June 06, 2013.

  • Pais T, Foulquié-Moreno MR, and Thevelein JM. 2014. QTL Mapping by Pooled-Segregant Whole Genome Sequencing in Yeast. Vol. 1152. Yeast Metabolic Engineering: Methods and Protocols , Methods in Molecular Biology,  Humana Press, Springer, USA. ISBN 978-1-4939-0562-1.316p.

  • Signori L, Passolunghi S, Ruohonen L, Porro D, Branduardi P. 2014. Effect of oxygenation and temperature on glucose-xylose fermentation in Kluyveromyces marxianus CBS712 strain. Microbial Cell Factories 13(1):51, 2014,  Apr 8,  doi: 10.1186/1475-2859-13-51.

  • Wallace-Salinas V, Gorwa-Grauslund MF. 2013. Adaptive evolution of an industrial strain of Saccharomyces cerevisiae for combined tolerance to inhibitors and temperature. Biotechnology for biofuels 6 (1): 151.

  • Wallace-Salinas V, Signori, LLi  Y-Y,  Ask M, Bettiga M, Porro D, Thevelein JM, Branduardi B, Foulquié-Moreno MR, Gorwa-Grauslund MF. 2014. Re-assessment of YAP1 and MCR1 contributions to inhibitor tolerance in robust engineered Saccharomyces cerevisiae fermenting undetoxified lignocellulosic hydrolysate. AMB Express 4 (1), 56.

  • Wallace-Salinas V, Signori L, Li YY, Ask M, Bettiga M, Porro D, Thevelein JM, Branduardi P, Foulquié-Moreno MR, Gorwa-Grauslund M. Re-assessment of YAP1 and MCR1 contributions to inhibitor tolerance in robust engineered Saccharomyces cerevisiae fermenting undetoxified lignocellulosic hydrolysate. 2014. AMB Express. 2014 Jul 22;4:56. doi: 10.1186/s13568-014-0056-5. eCollection 2014.

  • Yang Y., Foulquié-Moreno M., Erdei E., Schaerlaekens K., Dumortier F. and Thevelein J.M. 2013. QTL analysis of high thermotolerance with superior and downgraded parental yeast strains reveals new minor QTLs and converges on novel causative alleles involved in RNA processing. PLOS Genetics, doi: 10.1371/journal.pgen.1003693, August 15, 2013.

In Press

  • Bouzid O, de Vries RP. 2014. Overexpression of XlnR regulated hemicellulase-encoding genes in Aspergillus vadensis. Curr Biotechnol. In press.


  • Ellilä S, Bromann P, Nyyssönen M, Itävaara M, Marjamaa K, Koivula A, Paulin L, Kruus K. Isolation of novel xylanases from lignocellulose-enriched compost metagenomic libraries using functional screening and high-throughput sequencing (submitted 11/2013)

  • Moilanen U, Kellock M, Várnai A, Andberg M, Viikari L. Mechanisms of laccase-mediator treatments improving the enzymatic hydrolysis of pre-treated spruce  (submitted to Biotechnology for Biofuels (10/2014).

  • Rahikainen J, Moilanen U, Nurmi-Rantala S, Lappas, A, Koivula A, Viikari L and Kruus K. Effect of temperature and enzyme structure on unproductive cellulase adsorption onto

  • lignin (submitted).

  • Soh  KC, Miskovic L and Hatzimanikatis V. Systematic characterization of thermodynamic and metabolic flux spaces through Flux Directionality Profile Analysis (submitted).

  • Wiklund C, Mutturi S, Lidén G. Heat effects on the anaerobic metabolism of Saccharomyces cerevisiae in glucose-limited chemostat (submitted 02/2014).

  • Voutilainen SP, Nurmi-Rantala S, and Koivula A. 2013. Construction of thermostable cellulases with high activity on crystalline cellulose (submitted).


  • Wallace-Salinas V. 2014. Improving stress tolerance in industrial Saccharomyces cerevisiae strains for ethanol production from lignocellulosic biomass. PhD thesis, Division of Applied Microbiology, Lund University, Sweden.


Congress presentations

  • EU-China Science and Technology Week, World Expo, 14-19 June 2010, Shanghai, China
    Merja Penttilä, VTT
    Bioethanol for sustainable Transportation [PDF]

  • 14th International Biotechnology Symposium and Exhibition, IBS 2010, September 14-18, 2010, Rimini, Italy
    Merja Penttilä, VTT
    Novel high performance enzymes and micro-organisms for conversion of lignocellulosic biomass to bioethanol  [PDF]

  • The 2nd Nordic Wood Biorefinery Conference, NWBC-2009, 2 - 4 September 2009, Helsinki, Finland
    Merja Penttilä, VTT
    Novel high performance enzymes and micro-organisms for conversion of lignocellulosic biomass to bioethanol (NEMO)

  • International Workshop on Wood Biorefinery and Tree Biotechnology, 21 - 23 June 2010, Örnsköldsvik, Sweden
    Merja Penttilä, VTT
    Enzymes for plant biomass hydrolysis

  • Forum BioVision, The World Life Sciences Forum, 28 March 2011, Lyon, France
    Liisa Viikari, UH
    Biotechnical conversion of biomass to biofuels

  • 33rd symposium on biotechnology for fuels and chemicals, 4 May 2011, Seattle, USA
    Ulla Moilanen, UH
    The role of softwood and cane lignins in enzymatic hydrolysis

  • EPNOE, 2nd International Polysaccharide Conference, Polysaccharides as source of advanced and sustainable products; 29 August 2011, Wageningen, The Netherlands
    Liisa Viikari, UH
    Overcoming bottlenecks in lignocellulose conversion to platform sugars

  • ISSY28, 28th International Specialized Symposium on Yeasts, 'Metabolic and bioprocess engineering for sustainable development', Bangkok, Thailand
    Johan Thevelein, VIB
    Improved industrial yeast strains for bioethanol production: high ethanol tolerance

  • ISSY29, 29th International Specialized Symposium on Yeasts, 'The relevance of yeast and microbial consortia in traditional and industrial fermentations', 29 Aug.-2 Sept. 2011, Guadalajara, Mexico
    Johan Thevelein, VIB
    Polygenic analysis of tolerance to high ethanol levels in the yeast Saccharomyces cerevisiae

  • ACS Annual Meeting 16-20 August 2009, Washington, D.C., USA
    Vassily Hatzimanikatis, EPFL
    Optimization of ethanol production from xylose in Saccharomyces cerevisiae

  • Metabolic Engineering VIII: Metabolic Engineering for Green Growth, 13-17 June, 2010, Jeju, Korea
    Vassily Hatzimanikatis, EPFL
    Retrofitting Complex Systems for Green Growth

  • AIChE Annual Meeting, 7-12 November, 2010, Salt Lake City, USA
    Ljubisa Miskovič, EPFL
    Improving Ethanol Production of Xylose-Utilizing Saccharomyces cerevisiae

  • The XII International Congress on Molecular Systems Biology, 8-12 May, 2011, Lleida, Spain
    Vassily Hatzimanikatis, EPFL
    Model building and analysis under uncertainty

  • VIB-BGI Genomics meeting seminar in Leuven, Belgium. February 15, 2012
    Jean-Paul Mejnen, VIB
    Polygenic analysis of stress tolerance as a complex trait in Saccharomyces cerevisiae

  • Microbial Stress: from molecules to systems, 10-13 May 2012, Belgirate, Italy
    Maurizio Bettiga, CTH
    Robust yeast for feasible lignocellulose based production
    Eckhard Boles, GUF
    Bioethanol from Biomass, Simultaneous Fermentation of C6- and C5-Sugars under Very Harsh Conditions
    Vassily Hatzimanikatis, EPFL
    What’s the cost of stress management? Some considerations from flux balance and metabolic control analysis
    Valeria Wallace, ULUND
    Long-term adaptation of an industrial Saccharomyces cerevisiae strain: combining lignocellulosic-derived inhibitors robustness and thermotolerance

  • 8th International Conference on Renewable Resources and Biorefineries, 4-6 June 2012,Toulouse, France
    Sandra Hinz, DNL
    The xylanase machinery of Myceliophthora thermophila C1

  • Metabolic Engineering IX, 3-7 June 2012, Biarritz, France
    Vassily Hatzimanikatis, EPFL
    Development and Analysis of Genome-Scale Kinetic Models

  • Cobra Conference 2012, 7-9 October, 2012, Copenhagen, Denmark
    Vassily Hatzimanikatis, EPFL
    From COBRA to genome-scale kinetic models of metabolism

  • FOSBE 2012 Conference, 21-25 October, 2012, Tsuruoka, Japan
    Ljubisa Miskovic, EPFL
    Interplay Between Upper Glycolysis and Xylose Uptake Rate in Recombinant Xylose-Utilizing S. cerevisiae

  • Oxizymes, 16-19 September 2012, Marseille, France
    Johanna Rytioja, UH
    The expression of selected cellulose acting enzymes of the white-rot fungus Dichomitus squalens

  • 13th International Congress on Yeasts, August 26-30, 2012 Madison, WI, USA
    Magnus Ask, CTH
    HMF and furfural stress results in drainage of redox and energy charge of Saccharomyces cerevisiae
    Maurizio Bettiga, CTH
    Robust Microorganisms and Process Strategies– The Key to Successful Lignocellulose Based Production
    Mekonnen Demeke, VIB
    Development of xylose utilizing and inhibitor tolerant industrial yeast strain for second generation bio-ethanol production
    Thiago Pais, VIB
    QTL mapping of maximal ethanol accumulation capacity and high ethanol tolerance by pooled-segregant sequencing in a sake yeast strain

  • 6-8 December 2012, Visoça, Brazil
    Johan Thevelein, VIB
    Polygenic analysis of complex traits for development of superior industrial yeast strains

  • 3rd International Conference on Lignocellulosic Ethanol, 3-5 April 2013, Madrid, Spain
    Merja Penttilä, VTT
    Novel high performance enzymes and micro-organisms for conversion of lignocellulosic biomass to bioethanol
    Gunnar Lidén, ULUND
    Fermentation procedures – Some thoughts about mixing and temperature
    Johan Thevelein, VIB
    Development of superior xylose-fermenting and robust industrial yeast strains for lignocellulosic bioethanol production

  • Biorefinery for Food, Fuel and Materials, 7-10 April 2013, Wageningen, The Netherlands
    Sandra Hinz, DNL
    Functional analysis of the Myceliophthora thermophila C1 xylanase machinery

  • PYFF 5, 5th Conference on Physiology of Yeast and Filamentous Fungi, June 4 - 7, 2013, Montpellier, France
    Eckhard Boles, GUF
    Re-engineering of glucose transporters into xylose transporters for improved co-fermentation of mixed-sugar hydrolysates with Saccharomyces cerevisiae 

Press releases